Isobutyraldehyde → HCID 58460175, compound

Participants

Reaction Steps

Ammonium acetate (0.154 g) was dissolved in acetic acid (0.572 mL), to this was added Intermediate 65 (0.615 g), (1R)-1-phenylethanamine (0.362 mL) and isobutyraldehyde (0.216 mL, 2.363 mmol). The mixture was dissolved in chloroform (1.5 mL) and heated to reflux overnight. The mixture was reduced in vacuo and purified by column chromatography (0-100% ethyl acetate in cyclohexane). The appropriate fractions were concentrated in vacuo to yield 224 mg. LC/MS, MH+ 417, Rt 3.33 mins (5 min system, High ph).

Provenance & Evidence