Isobutyraldehyde → HCID 58460189, compound

Participants

Reaction Steps

Ammonium acetate (0.154 g) was dissolved in acetic acid (0.572 mL), to this was added Intermediate 65 (0.560 g), (1R)-1-(4-chlorophenyl)ethanamine (0.362 mL) and isobutyraldehyde (0.196 mL), the mixture dissolved in chloroform (2 mL) and heated to reflux overnight. The mixture was reduced in vacuo and purified by column chromatography (0-100% ethyl acetate in cyclohexane). The appropriate fractions were concentrated in vacuo to yield the racemic mixture of the desired regioisomer. LC/MS MH+ 452, Rt 3.50 mins (5 min run, High pH).

Provenance & Evidence