Hydrochloric Acid → HCID 58460202, compound

Participants

Reaction Steps

A solution of Intermediate 78 (128 mg, two batches) in Methanol (3.5 mL) and potassium hydroxide (10M aqueous soln) (0.749 mL) was heated to reflux overnight. LCMS after 18 h indicated approximately 20% conversion to the acid. Further potassium hydroxide (10M aqueous soln) (0.749 mL was added to the reaction mixture and it was left to heat for a further 36 h. LCMS after this time demonstrated full conversion to the acid product. Aqueous HCl (4.85 mL) was added to the reaction mixture to neutralise to the KOH. The product was extracted from the reaction mixture using EtOAc. The organic layer was washed with water, brine and then dried over MgSO4 and filtered, before being concentrated in vacuo to give the product, 88 mg. LC/MS MH+ 361, Rt 2.02 mins (5 min run, TFA modifier).

Provenance & Evidence