反应详情

A solution of (E)-2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine (0.25 g, 0.8 mmol) and ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (0.13 g, 0.57 mmol) in DME was stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated aqueous solution of bicarbonate, water, acetic acid and sodium acetate (pH=4), dried over sodium sulfate and solvent evaporated. The resulting crude residue was purified by flash chromatography (0% to 30% ethyl acetate in hexane) to afford title compound 116 (0.265 g, quant.).

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washwas washed with saturated aqueous solution of bicarbonate, water, acetic acid and sodium acetate (pH=4)
4. dry with materialdried over sodium sulfate and solvent
5. customevaporated
6. customThe resulting crude residue was purified by flash chromatography (0% to 30% ethyl acetate in hexane)