Methyl 5-(2-(methoxycarbonyl)phenoxy)-4-nitrothiophene-2-carboxylate → HCID 59783603, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of compound 118 (1.918 g, 5.69 mmol) in acetic acid was added iron (2.223 g, 39.8 mmol) and the reaction mixture was stirred at 85° C. for 1 h then at 100° C. for 1 h. The mixture was cooled to room temperature, poured into 150 mL of ice-cold water and the resulting white precipitate was filtered to afford title compound 119 (1.261 g, 81%) as a beige solid. LRMS (ESI): (calc) 275.03 (found) 276.2 (MH)+.

Provenance & Evidence