HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1s,4s)-2-Benzhydryl-2,5-diazabicyclo[2.2.1]heptane2hcl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 70672817 | HCID 70672817 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1s,4s)-2-Benzhydryl-2,5-diazabicyclo[2.2.1]heptane2hcl | HCID 67006897 | 59% |
Reaction Steps
A solution of compound 200 (0.5 g, 1.37 mmol) in 4N HCl in dioxane (5 mL) was stirred for 1 h at room temperature and then concentrated. The residue was purified by trituration with Et2O and filtered to afford 201 (0.24 g, 59%) as a beige solid. LRMS (ESI): (calc) 264.2 (found) 265.3 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399452B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-81510a7a36504e50b4b87b95cff1d6c4 |
| Source note | uspto-grants-2013_03 |