HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (Z)-4((5H-dibenzo[b,f]azepin-5-yl)methyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (Z)-methyl 4-((5H-dibenzo[b,f]azepin-5-yl)methyl)benzoate | HCID 59783517 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (Z)-4((5H-dibenzo[b,f]azepin-5-yl)methyl)benzoyl chloride | HCID 59783850 | — |
Reaction Steps
The title compound 390 (0.72 g, 2.2 mmol) and the oxalyl chloride (0.58 mL, 6.6 mmol) were mixed in DCM (10 mL) and few drops of DMF was added. The reaction mixture was stirred for 30 minutes and the solvent was evaporated (and stripped with toluene twice) to afford title compound 391 that was used crude for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399452B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-eca1ad1ec7274e80b1b66752ca66e233 |
| Source note | uspto-grants-2013_03 |