HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-amino-2-fluorobenzoate → HCID 25183072, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-amino-2-fluorobenzoate | HCID 21957875 | — |
| Reactant | 6-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid | HCID 59446841 | — |
| Product | HCID 25183072 | HCID 25183072 | — |
Reaction Steps
outlined in Example 1, starting from 6-(cyclohexyl-cyclopropylmethyl-amino)-pyrimidine-4-carboxylic acid (Intermediate 13) and 4-amino-2-fluoro-benzoic acid methyl ester (Bepharm), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-329d53cd2fd34e3a8984d9a1016e16b2 |
| Source note | uspto-grants-2013_03 |