4-Amino-3-methylbenzene-1-sulfonamide → HCID 25182756, compound

HRID 1946720Notes

Reaction equation

HRID 1946720 reaction equation
[CH:1]1([NH:7][C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([OH:16])=O)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[CH:20][C:19]=1[CH3:28]>CO>[NH2:27][S:24]([C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:14]([C:10]2[CH:9]=[C:8]([NH:7][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[N:13]=[CH:12][N:11]=2)=[O:16])=[C:19]([CH3:28])[CH:20]=1)(=[O:25])=[O:26]

Participants

4

Reactant 2

HCID 1430374-Amino-3-methylbenzene-1-sulfonamideHCID 594470756-(Cyclohexylamino)pyrimidine-4-carboxylic acid2×

Product 1

HCID 25182756HCID 25182756, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and 4-amino-3-methyl-benzenesulfonamide (Biofocus), the title compound was obtained as a white solid after trituration in methanol.

Sources & evidence

ORD record
ord-b17ab99bffa04ea4852fa6d145944ccf
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Reaction notes

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