HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylcyclohexylamine → 6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylcyclohexylamine | HCID 7514 | — |
| Reactant | 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 59447105 | — |
| Product | 6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 25182759 | — |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and N-methylcyclohexylamine (Aldrich), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-be91b69cc54c4366a1f6e9468f6184d1 |
| Source note | uspto-grants-2013_03 |