HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-amino-3-methoxyphenyl)methanesulfonamide → 6-(cyclohexylamino)-N-{2-methoxy-4-[(methylsulfonyl)amino]phenyl}pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-amino-3-methoxyphenyl)methanesulfonamide | HCID 290500 | — |
| Reactant | 6-(Cyclohexylamino)pyrimidine-4-carboxylic acid | HCID 59447075 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(cyclohexylamino)-N-{2-methoxy-4-[(methylsulfonyl)amino]phenyl}pyrimidine-4-carboxamide | HCID 25182764 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-(cyclohexylamino)pyrimidine-4-carboxylic acid (Intermediate 4) and N-(4-amino-3-methoxyphenyl)methanesulfonamide (Kaironkem), the title compound was obtained as a white solid after trituration in DCM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-dc9d36f2cc06426eb92bb938d2228e73 |
| Source note | uspto-grants-2013_03 |