HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indazol-5-amine → 6-[cyclohexyl(methyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indazol-5-amine | HCID 88012 | — |
| Reactant | 6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid | HCID 59447077 | — |
| Product | 6-[cyclohexyl(methyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide | HCID 25182770 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 5-aminoindazole (Aldrich), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-858859c9c2c04209a3a9cd0d405eb5f7 |
| Source note | uspto-grants-2013_03 |