HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide → HCID 59446946, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 59447105 | — |
| Solvent | (+-)-2-Butanol | HCID 6568 | — |
| Product | HCID 59446946 | HCID 59446946 | — |
Reaction Steps
Following the general method as outlined in Example 26, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and 2-butanol (Fluka), the title compound was obtained as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-44e6f4baffa54f3dbf866e5e29e0dc8c |
| Source note | uspto-grants-2013_03 |