HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide → 6-[cyclohexyl(methyl)amino]-N-(4-{[(2,3-dihydroxypropyl)amino]sulfonyl}phenyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide | HCID 59446956 | — |
| Reactant | 6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid | HCID 59447077 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-[cyclohexyl(methyl)amino]-N-(4-{[(2,3-dihydroxypropyl)amino]sulfonyl}phenyl)pyrimidine-4-carboxamide | HCID 25182775 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-amino-N-(2,3-dihydroxypropyl)benzenesulfonamide (Intermediate 14), the title compound was obtained as a white solid after trituration in DCM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-613dd874104c4c0c8575e9edb8d45535 |
| Source note | uspto-grants-2013_03 |