HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminoquinoline → 6-[cyclohexyl(methyl)amino]-N-quinolin-4-ylpyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminoquinoline | HCID 68476 | — |
| Reactant | 6-[Cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid | HCID 59447077 | — |
| Product | 6-[cyclohexyl(methyl)amino]-N-quinolin-4-ylpyrimidine-4-carboxamide | HCID 25182777 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(methyl)amino]pyrimidine-4-carboxylic acid (Intermediate 10) and 4-aminoquinoline (Tyger), the title compound was obtained as an off-white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-83a181b32e8e4015ba49afa331c7d2cf |
| Source note | uspto-grants-2013_03 |