HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 6-[cyclohexyl(cyclopropylmethyl)amino]-N-pyridin-4-ylpyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 6-[Cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid | HCID 59446841 | — |
| Product | 6-[cyclohexyl(cyclopropylmethyl)amino]-N-pyridin-4-ylpyrimidine-4-carboxamide | HCID 25182903 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid (Intermediate 13) and 4-aminopyridine (Tyger), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-842dd64c11044ead9bc73baeeed1d17f |
| Source note | uspto-grants-2013_03 |