6-methyl-1H-indazol-5-amine → 6-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

HRID 1946767Notes

Reaction equation

HRID 1946767 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:18][C:19]1[CH:27]=[C:26]2[C:22]([CH:23]=[N:24][NH:25]2)=[CH:21][C:20]=1[NH2:28]>>[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([NH:28][C:20]3[CH:21]=[C:22]4[C:26](=[CH:27][C:19]=3[CH3:18])[NH:25][N:24]=[CH:23]4)=[O:14])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 14825826-methyl-1H-indazol-5-amineHCID 594470006-[(Cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 251829156-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

Procedure

Following the general method as outlined in Example 1, starting from 6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid (Intermediate 21) and 6-methyl-1H-indazol-5-yl-amine (Bionet), the title compound was obtained as a pale brown solid.

Sources & evidence

ORD record
ord-519e497e992942d0be52ba0a706a6af4
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Reaction notes

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