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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1946774Generated: November 1, 2026

Methyl 2-aminoisobutyrate hydrochloride → HCID 25182927, compound

https://huagongshe.com/reaction/1946774

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-aminoisobutyrate hydrochlorideHCID 13258034—
Reactant6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamideHCID 59446846—
ProductHCID 25182927HCID 25182927—

Reaction Steps

Following the general method as outlined in Example 73, starting from 6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide (Intermediate 24) and 2-aminoisobutyric acid methyl ester hydrochloride (Sigma), the title compound was obtained as a colorless oil after purcation by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399448B2
Source datasetuspto-grants-2013_03
ORD IDord-f774999540654a9c996ab3cd873b08b3
Source noteuspto-grants-2013_03