(4-Amino-3-methylphenyl)methanol → HCID 25182929, compound

HRID 1946776Notes

Reaction equation

HRID 1946776 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=2)[CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21][C:20]=1[CH3:27]>>[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21][C:20]=3[CH3:27])=[O:14])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 1514189(4-Amino-3-methylphenyl)methanol2×HCID 594470006-[(Cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid2×

Product 1

HCID 25182929HCID 25182929, compound

Procedure

Following the general method as outlined in Example 1, starting from 6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid (Intermediate 21) and (4-amino-3-methylphenyl)methanol (Intermediate 28), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.

Sources & evidence

ORD record
ord-c1f7f3a8ed6c40829bd96a48c0f7b8ed
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Reaction notes

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