HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine, N-propyl- → N-[4-(aminomethyl)phenyl]-6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine, N-propyl- | HCID 117787 | — |
| Reactant | Tert-butyl (4-{[(6-chloropyrimidin-4-yl)carbonyl]amino}benzyl)carbamate | HCID 59447092 | — |
| Product | N-[4-(aminomethyl)phenyl]-6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxamide | HCID 25182932 | — |
Reaction Steps
Following the general method as outlined in Example 72 (Steps 1 and 2), starting from tert-butyl (4-{[(6-chloropyrimidin-4-yl)carbonyl]amino}benzyl)carbamate (Intermediate 22) and N-propylcyclopropanemethylamine (Aldrich), the title compound was obtained as a beige solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b294d9499870424d86d2ff9b582ca139 |
| Source note | uspto-grants-2013_03 |