HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Cyclopropylmethyl)(2-methoxyethyl)amine → 6-[(cyclopropylmethyl)(2-methoxyethyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Cyclopropylmethyl)(2-methoxyethyl)amine | HCID 19353678 | — |
| Reactant | 6-chloro-N-1H-indazol-5-ylpyrimidine-4-carboxamide | HCID 59446880 | — |
| Product | 6-[(cyclopropylmethyl)(2-methoxyethyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide | HCID 25182934 | — |
Reaction Steps
Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (1H-indazol-5-yl)-amide (Intermediate 16) and N-(cyclopropylmethyl)-2-methoxyethanamine, the title compound was obtained as a beige solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a58908a0d2a64075b9d35c1d123341c3 |
| Source note | uspto-grants-2013_03 |