HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylsulfonyl)aniline → 6-[(cyclopropylmethyl)(propyl)amino]-N-[4-(methylsulfonyl)phenyl]pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylsulfonyl)aniline | HCID 79617 | — |
| Reactant | 6-[(Cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid | HCID 59447000 | — |
| Product | 6-[(cyclopropylmethyl)(propyl)amino]-N-[4-(methylsulfonyl)phenyl]pyrimidine-4-carboxamide | HCID 59447050 | — |
Reaction Steps
Following the general method as outlined in Example 1, starting from 6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid (Intermediate 21) and 4-(methylsulfonyl)aniline (Enamine), the title compound was obtained as a white solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399448B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d69b148a8eeb46e695fea0bf47aaaa14 |
| Source note | uspto-grants-2013_03 |