Water → 2-Amino-2-(3-bromophenyl)propan-1-ol

Temperature

-7 °C

A solution of the (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester (9.39 g, mmol) in tetrahydrofuran (360 ml) was treated portionwise at −5° C. with lithiumaluminiumhydride (1.41 g, 36 mmol; 282 mg/2 min). After complete addition, stirring was continued at 0-5° C. for 30 minutes. For the workup, the reaction mixture was cooled to −7° C., and water (9 ml) was added dropwise. Thereafter, 2 N sodium hydroxide solution (9 ml) was added and stirring continued for 15 minutes at room temperature. They grey suspension was filtrated through Dicalite which was washed with tetrahydrofuran (200 ml). The filtrate was evaporated at reduced pressure. There were obtained 8.67 g of crude (RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol as colorless oil. The purity of the product allowed using it in the next step without further purification. MS (ISP): m/z=230.1 [M+H]+, 232.0 [M+2+H]+.

1. additionAfter complete addition
2. stirringstirring
3. waitcontinued for 15 minutes at room temperature
4. filtrationThey grey suspension was filtrated through Dicalite which
5. washwas washed with tetrahydrofuran (200 ml)
6. customThe filtrate was evaporated at reduced pressure

ORD record

ord-f505b0729a51410a96554694c167f652

Source dataset

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08399459B2