反应详情

In a manner analogous to that described for intermediate IX-1 the acylation of (R)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol with chloro-acetyl chloride yielded the N—[(R)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide as a light yellow oil (9.30 g, 90% of theory; e.e. >96%). MS (ISP): m/z=322.0 [M+H]+, 324.0 [M+2+H]+, 326.0 [M+4+H]+.