Pyridinium hydrochloride → HCID 68153395, compound

Participants

Reaction Conditions

Reaction Steps

A sealed tube was charged with 5-[1-(3-bromo-phenyl)-vinyl]-2-methoxy-pyridine (600 mg) and pyridinium hydrochloride (3 g) freshly prepared. The tube was heated at 125° C. for 10 minutes, then the mixture was allowed to cool to room temperature. The crude was dissolved in dichloromethane (15 ml), the solution washed with hydrochloric acid (1N) (2×15 ml), dried over sodium sulphate and evaporated. The crude product was purified by flash chromatography eluting with cyclohexane/ethyl acetate. The 5-[1-(3-bromo-phenyl)-vinyl]-1H-pyridin-2-one was obtained as a colorless oil (366 mg, 64% of theory). MS (ISP): m/z=278 [M+H]+.

Provenance & Evidence