Chloroacetyl chloride → HCID 68153562, compound

Participants

Reaction Steps

In close analogy to the reaction sequence described for the preparation of intermediate X-1, the acylation of the (RS)-2-amino-2-(3-bromo-phenyl)-2-(6-difluoromethoxy-pyridin-3-yl)-ethanol with chloroacetylchloride followed by cyclisation with tert-butanol and potassium tert-butanolate yielded the (RS)-5-(3-bromo-phenyl)-5-(6-difluoromethoxy-pyridin-3-yl)-morpholin-3-one as a light yellow solid (1.6 g, 91% of theory). MS (ISP): m/z=400.9 [M+H]+.

Provenance & Evidence