Lawesson's reagent → HCID 86668500, compound

Participants

Reaction Steps

A mixture of (RS)-5-(3-bromo-phenyl)-5-(6-difluoromethoxy-pyridin-3-yl)-morpholin-3-one (1.6 g, 1.0 eq) and Lawesson's reagent (2.0 g, 1.2 eq) in tetrahydrofuran (60 ml) was stirred at room temperature overnight. For the workup, the solvent was removed at reduce pressure. The crude product was purified by chromatography on silica gel using a gradient of hexane/ethyl acetate as the eluent. The (RS)-5-(3-bromo-phenyl)-5-(6-difluoromethoxy-pyridin-3-yl)-morpholin-3-thione was obtained as a yellow foam (1.0 g, 83% of theory). MS (ISP): m/z=415 [M+H]+.

Provenance & Evidence