Ethyl Acetate → HCID 68153540, compound

Participants

Reaction Steps

A solution of (RS)-5-(3-[1,3]dioxolan-2-yl-phenyl)-5-methyl-morpholin-3-one (1.49 g, 5.7 mmol) in a mixture of tetrahydrofuran (65 ml) and water (13 ml) was treated with potassium monopersulphate (5.21 g, 8.5 mmol) under stirring at room temperature for 3 hours. For the workup, water (20 ml) and ethyl acetate were added. The organic layer was separated, washed with water (2×20 ml). The organic layer was dried over sodium sulphate and evaporated at reduced pressure. The 3-((RS)-3-methyl-5-oxo-morpholin-3-yl)-benzoic acid obtained (0.9 g, 67% of theory) was pure and could be used in the next step without further purification.

Provenance & Evidence