Nitroxyl → HCID 60141066, compound

Participants

Reaction Steps

In close analogy to the reaction sequence described in Example 31 (method B), the palladium-catalyzed coupling of (RS)-3-(5-bromo-2-fluoro-phenyl)-5-methoxy-3-methyl-3,6-dihydro-2H-[1,4]oxazine (intermediate XI-2) with pyrimidine-5-boronic acid followed by the treatment of the corresponding imino-ether with ammonium chloride yielded the 5-(2-fluoro-5-pyrimidin-5-yl-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine as a white foam. MS (ISP): m/z=302.2 [M+H]+.

Provenance & Evidence