Tetrabutylammonium Fluoride → HCID 60141493, compound

Participants

Reaction Steps

In a manner analogous to that described in Example 42, the reaction of (RS)-5-(3-iodo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine (intermediate XII-2) with 5-chloro-2-trimethylsilanylethynyl-pyridine (EP385210) was performed. In addition, after combination of solution 1 and 2, a solution of tetrabutylammonium fluoride in tetrahydrofuran (1M, 0.47 ml) was added. The 5-[3-(5-chloro-pyridin-2-ylethynyl)-phenyl]-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine was obtained as a white foam. MS (ISP): m/z=326.3 [M+H]+.

Provenance & Evidence