Lawesson's reagent → HCID 86668502, compound

HRID 1946935Notes

Reaction equation

HRID 1946935 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[N:6]=[C:7]([C:9]3[CH:10]=[C:11]([C:15]4([CH3:22])[NH:20][C:19](=O)[CH2:18][O:17][CH2:16]4)[CH:12]=[CH:13][CH:14]=3)[O:8][C:4]=2[CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[N:6]=[C:7]([C:9]3[CH:10]=[C:11]([C:15]4([CH3:22])[NH:20][C:19](=[S:34])[CH2:18][O:17][CH2:16]4)[CH:12]=[CH:13][CH:14]=3)[O:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 68153471HCID 68153471, compound

Product 1

HCID 86668502HCID 86668502, compoundYield 79%

Procedure

In close analogy to the procedure described for the preparation of Intermediate XVIII-1, the reaction of (RS)-5-[3-(6-chloro-benzooxazol-2-yl)-phenyl]-5-methyl-morpholin-3-one with Lawesson's reagent yielded the title compound (79% of theory). MS (ISP): m/z=359.1 [M+H]+.

Workup

  1. customIn close analogy to the procedure described for the preparation of Intermediate XVIII-1

Sources & evidence

ORD record
ord-04fc05cc2eac4b8aa8131a8cfe980cc5
Source dataset
uspto-grants-2013_03
Patent number
US08399459B2

Reaction notes

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