2-Amino-4-chlorophenol → HCID 68153442, compound

HRID 1946938Notes

Reaction equation

HRID 1946938 reaction equation
[CH3:1][C:2]1([C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([OH:14])=O)[CH2:7][O:6][CH2:5][C:4](=[O:8])[NH:3]1.[NH2:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1O>>[Cl:25][C:23]1[CH:22]=[CH:21][C:20]2[O:14][C:12]([C:11]3[CH:10]=[C:9]([C:2]4([CH3:1])[NH:3][C:4](=[O:8])[CH2:5][O:6][CH2:7]4)[CH:17]=[CH:16][CH:15]=3)=[N:18][C:19]=2[CH:24]=1

Participants

3

Reactant 2

HCID 72652-Amino-4-chlorophenolHCID 68153540HCID 68153540, compound

Product 1

HCID 68153442HCID 68153442, compound

Procedure

The condensation of 3-((RS)-3-methyl-5-oxo-morpholin-3-yl)-benzoic acid (intermediate XXVI-1) and 2-amino-4-chloro-phenol with polyphosphoric acid at 130° C. during 3 hours yielded the title compound.

Sources & evidence

ORD record
ord-381f758b80bd4d9e945915a99c5cecae
Source dataset
uspto-grants-2013_03
Patent number
US08399459B2

Reaction notes

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