Acetic Acid → HCID 178420390, compound

HRID 1946970Notes

Reaction equation

HRID 1946970 reaction equation
[CH2:1]([O:8][C:9]1[CH:40]=[CH:39][CH:38]=[CH:37][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[CH:15][N:16](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(O)=O>CO>[CH2:1]([O:8][C:9]1[CH:40]=[CH:39][CH:38]=[CH:37][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 59742744HCID 59742744, compound

Product 1

HCID 178420390HCID 178420390, compoundYield 60.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

A solution of 4-(2-benzyloxy-phenoxymethyl)-1-trityl-1H-imidazole (34 mg) in MeOH (2 ml) was treated with AcOH (0.1 ml) and was heated to 70° C. for 5 hours. The mixture was concentrated. The crude product was purified by column chromatography to give 4-(2-benzyloxy-phenoxymethyl)-1H-imidazole (11 mg) as a colorless amorphous solid. MS (ISP): 281.4 ([M+H]+)

Workup

  1. concentrationThe mixture was concentrated
  2. customThe crude product was purified by column chromatography

Sources & evidence

ORD record
ord-b4b49d1c76d741f78d7d3bdd07fc301a
Source dataset
uspto-grants-2013_03
Patent number
US08399463B2

Reaction notes

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