3-Morpholinophenol → HCID 178420465, compound

HRID 1946971Notes

Reaction equation

HRID 1946971 reaction equation
ClCC1N=CN(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1.[O:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:34]=[C:35](O)[CH:36]=[CH:37][CH:38]=2)[CH2:29][CH2:28]1.[NH:40]1[CH:44]=[C:43]([CH2:45][O:46]C2C=C(N3CCOCC3)C=CC=2)[N:42]=[CH:41]1>>[NH:40]1[CH:44]=[C:43]([CH2:45][O:46][C:38]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[N:30]2[CH2:31][CH2:32][O:27][CH2:28][CH2:29]2)[N:42]=[CH:41]1

Participants

4

Reactant 3

HCID 1413433-MorpholinophenolHCID 27631764-(Chloromethyl)-1-trityl-1H-imidazoleHCID 178420713HCID 178420713, compound

Product 1

HCID 178420465HCID 178420465, compound

Procedure

In analogy to example 20, 4-chloromethyl-1-trityl-1H-imidazole (CAS103057-10-9) was reacted with 3-morpholinophenol and converted to 4-[3-(1H-imdazol-4-ylmethoxy)-phenyl]-morpholine as a white solid. MS (ISP): 260.3 ([M+H]+)

Sources & evidence

ORD record
ord-1157810956f24ec7baa001ba7a7844ed
Source dataset
uspto-grants-2013_03
Patent number
US08399463B2

Reaction notes

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