HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-amino-N,N-dimethylcyclohexane-1-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Tert-butyl{4-[(dimethylamino)carbonyl]cyclohexyl}carbamate | HCID 69309396 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-amino-N,N-dimethylcyclohexane-1-carboxamide hydrochloride | HCID 67541542 | — |
Reaction Steps
HCl (concentrated, 7 mL) was added to a solution of (4-dimethylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester (1.5 g) in 1,4-dioxane (20 mL), and the resulting mixture was stirred at RT for 5 h. Toluene was added and the reaction mixture was evaporated under reduced pressure. The oily residue was triturated with EtOAc to give 4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride salt (0.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399462B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b912331ca7014f85b21ccb6be4a13eab |
| Source note | uspto-grants-2013_03 |