Hydrochloric Acid → HCID 178524197, compound

Participants

Reaction Steps

LAH (327 mg, 13.6 mmol) was added to a suspension of 1-[2-(4-hydroxycyclohexylamino)-pyrimidin-4-yl]-1H-indole-4-carboxylic acid methyl ester (1.0 g, 2.7 mmol) in a mixture of THF (4 mL), water (4 mL) and MeOH (1 mL). The reaction mixture was stirred at RT for 16 h, then evaporated under reduced pressure to give a beige solid. Aqueous HCl (1 M, 14 mL) was added to the residue, and the resulting mixture was stirred and evaporated under reduced pressure. The residue was triturated with MeOH to give trans-1-[2-(4-hydroxycyclohexylamino)-pyrimidin-4-yl]-1H-indole-4-carboxylic acid (700 mg) as an off-white solid. MS=353 [M+H]+; MP=259.0-261.0° C.

Provenance & Evidence