HCID 24959895, compound → HCID 178515632, compound

Participants

Reaction Steps

A mixture of 4-[4-(5-benzyloxyindol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol (70 mg) and Pd/C (15%, 38 mg) in EtOH was stirred under H2 (balloon pressure) at RT for 4 days. The reaction mixture was then filtered through a CELITE™ pad, the filter cake washed with EtOH, and the filtrate evaporated under reduced pressure. The residue was purified by flash chromatography (DCM/MeOH, 95:5) to give trans-1-[2-(4-hydroxy-cyclohexylamino)-pyrimidin-4-yl]-1H-indol-5-ol (51 mg) as an off-white solid. MS=325 [M+H]+; MP=246.5-248.0° C.

Provenance & Evidence