反应详情

4,5-Bis(bromomethyl)-3-hydroxy-2-methylpyridine (2)(3 g, 0.008 mol) was stirred in water (24 ml) at 45-50° C. for 40 min. The solution was filtered and evaporated under vacuum. The obtained residue was crystallized from ethanol. The yield was 1.2 g (50%). The position of bromomethyl- in pyridine-ring was verified by qualitative analysis with 2,6-dichloroquinone-4-chloroimide (Harris and Folkers (1939) J. Am. Chem. Soc. 61: 247). M.p. 158-159° C.

1. filtrationThe solution was filtered
2. customevaporated under vacuum
3. customThe obtained residue was crystallized from ethanol