Potassium Carbonate → HCID 69311856, compound

Participants

Reaction Steps

(2-Fluoro-4-hydroxyphenyl)-(2-methylsulfanyl-pyrimidin-4-yl)-methanone (2.26 g, 12.7 mmol), K2CO3 (3.5 g, 25.4 mmol) and 1-methylthio-4-tosylbutane (8.5 g, 44.5 mmol) were stirred in NMP for 1 h at 100° C., cooled to RT, filtered, diluted with water, and extracted into EtOAc. The combined organic layers were dried over sodium sulfate, filtered, concentrated in vacuo and purified by flash chromatography on a silica column eluting with hexane:ethyl acetate 9:1 to 3:2 to yield [2-fluoro-4-(4-methylsulfanyl-butoxy)-phenyl]-(2-methylsulfanyl-pyrimidin-4-yl)-methanone (3.42 g).

Provenance & Evidence