Diisopropylethylamine → HCID 69309534, compound

Participants

Reaction Steps

(4-hydroxy-piperidin-1-yl)-(4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexyl)-methanone (0.855 g, 2.116 mM) and piperidin-4-ylmethyl-carbamic acid t-butyl ester (0.907 g, 4.232 mM) were mixed in THF (40 mL) for approximately 2 h with diisopropylethylamine (1.47 mL, 8.464 mM) and BOP (1.87 g, 4.23 mM) to yield a fine solid that was purified on an alumina column with 1-3% MeOH/CH2Cl2, dried and extracted into EtOAc to yield [1-(4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarbonyl)-piperidin-4-ylmethyl]-carbamic acid t-butyl ester as a white powder upon drying in vacuo (0.856 g).

Provenance & Evidence