Tetrabutylammonium Fluoride → HCID 59743545, compound

Participants

Reaction Steps

N-[4-(4-{4-[3-(t-butyl-dimethylsilanyloxy)-pyrrolidin-1-yl]-indol-1-yl}-pyrimidin-2-ylamino)-cyclohexyl]-methanesulfonamide (0.35 mmol) was mixed with TBAF (10 eq, 3.5 mL) in anhydrous THF (15 mL) and allowed to stir for 1.5 h at RT, and then heated to 68° C. The reaction mixture was washed with NH4Cl/H2O, extracted into EtOAc (6×15 mL), and further washed with H2O (6×30 mL). The product was isolated via chromatography (prep. TLC in NH4OH/MeOH/DCM) as N-[4-(4-{4-[3-(hydroxy)-pyrrolidin-1-yl]-indol-1-yl}-pyrimidin-2-yl-amino)-cyclohexyl]-methanesulfonamide (Compound 311, 35 mg).

Provenance & Evidence