Imidazole → HCID 15307470, compound

Participants

Reaction Steps

Tri-isopropylsilyl chloride (TIPS-Cl, 15.86 mL) and imidazole (5.62 g) were added to 1H-indol-4-ol (10 g) in DMC (200 mL), and stirred at RT overnight. The resulting solid was filtered and washed with DCM. The filtrate was concentrated and purified on a column with 100% hexane to 25% EtOAc/hexane, and the fractions collected, concentrated, triturated with cold hexane, and the resulting solid was filtered and dried at 50° C. to yield 4-(triisopropylsilyl-oxy)-1H-indole (17 g, ˜80%).

Provenance & Evidence