m-Chloroperbenzoic acid → HCID 69309652, compound

Participants

Reaction Steps

4,4,4-Trifluoro-1-[1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indol-4-yloxy]-butan-2-ol (1.5 g) in CHCl3 (200 mL) at 0° C. was stirred for 3 h with MCPBA (0.962 g) at 0° C., then quenched with 10% aqueous sodium thiosulfate. The organic layer was separated, washed with saturated NaHCO3 and brine, dried over sodium sulfate, filtered, concentrated in vacuo and purified on a column with 100% DCM to 15% MeOH/DCM (product eluting at 5% MeOH) to yield 4,4,4-trifluoro-1-[1-(2-methylsulfinyl-pyrimidin-4-yl)-1H-indol-4-yloxy]-butan-2-ol (˜1.4 g).

Provenance & Evidence