Diisopropylethylamine → HCID 59743422, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-amino-cyclohexyl)-N-methyl-methanesulfonamide (567 mg, 2.12 mmol) and DIEA (0.44 mL) were stirred in NMP (0.7 mL) at RT for 1 h. [1-(2-Methanesulfinyl-pyrimidin-4-yl)-1H-indol-4-ylmethyl]-(2-methoxyethyl)-methyl-amine (305 mg, 0.85 mmol) in NMP (0.8 mL) was added, and the tube sealed and heated to 130° C. for 1 h. The mixture was then cooled to RT, decanted into water, stirred at RT overnight, and the filtrate filtered off and dried in vacuo, dissolved in DCM/ether, the precipitate filtered off, and the residue concentrated and crystallized from DCM/ether to yield N-{4-[4-(4-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexyl}-N-methyl-methanesulfonamide (Compound 203).

Provenance & Evidence