Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Aminocyclohexanecarboxylic acid | HCID 171560 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 66672581 | HCID 66672581 | — |
Reaction Steps
4-Amino-cyclohexanecarboxylic acid (16 g, 0.11 mol) was treated with K2CO3 (46.8 g) in MeCN (225 mL) at 80° C. under Ar. Benzyl bromide (46.6 mL) in MeCN (140 mL) was then added dropwise and stirred at 80° C. for approximately 20 hours and allowed to cool to RT, to yield 4-dibenzylamino-cyclohexanecarboxylic acid benzyl ester (55.04 g) after workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399462B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-a65d53467fdd48729a68e65e48ee25a1 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
