Acetic Acid → HCID 69307251, compound

Participants

Reaction Steps

2-(4-Dibenzylamino-cyclohexyl)-propan-2-ol (15 g) in EtOH (300 mL, abs) was treated with Pd(OH)2 (12.5 g). Acetic acid (6.3 mL) was added, and H2 was added slowly over 4.5 h. The reaction mixture was allowed to stand, then was filtered through a glass frit, washed with EtOH, filtered through a second glass frit, and the solvent removed in vacuo. The product was dissolved in hexane, and the hexane removed in vacuo (×3). The product was then triturated with ether, and the resultant solid filtered. The filtrate was evaporated, the residue dissolved in EtOH and solvent removed in vacuo. The product was then triturated in ether and the product filtered. The solvent was removed from both solid portions to yield 2-(4-aminocyclohexyl)-propan-2-ol acetate (6.52 g).

Provenance & Evidence