m-Chloroperbenzoic acid → HCID 86620845, compound

Participants

Reaction Steps

MCPBA (77%) was added dropwise to 3-[1-(2-butylsulfanyl-pyrimidin-4-yl)-1H-indol-4-yloxy]-propane-1-sulfonic acid amide (1.317 g, 3.13 mmol) in DCM (20 mL) at 0° C. The reaction mixture was allowed to warm to RT, and stirred for 1 h. Sodium bisulfite (10%) was them added, the mixture extracted with DCM, washed with NaHCO3 solution, water, and brine, dried over sodium sulfate, filtered and the solvent removed in vacuo to yield 3-[1-(2-butyl-sulfinyl-pyrimidin-4-yl)-1H-indol-4-yloxy]-propane-1-sulfonic acid amide (77.5%).

Provenance & Evidence