Diisopropylethylamine → HCID 59743610, compound

Participants

Reaction Steps

1-(2-Butylsulfonyl-pyrimidin-4-yl)-1H-indole-3-sulfonic acid amide (250 mg, 0.634 mmol), trans-(N-methyl-N-methylsulfonyl)cyclohexyldiamine acetate (422 mg, 1.584 mmol) and N-ethyl-diisopropylamine (205 mg, 1.584 mmol) were combined in a microwave vial, NMP added under N2, and the vial capped and stirred for 5 min at RT. The vial was then heated to 170° C. in a microwave reactor for 2.5 h, and left to stand at RT overnight. The mixture was then poured into ice water, and the resulting light yellow solid filtered, washed with water (30 mL) and Et2O (40 mL) and air-dried. The crude product was recrystallized from EtOAc-CHCl3 to provide 1-{2-[4-(methanesulfonyl-methyl-amino)-cyclohexylamino]-pyrimdin-4-yl}-1H-indole-3-sulfonic acid amide (183 mg, 60% yield) as a light yellow solid (Compound 321).

Provenance & Evidence