Diisopropylethylamine → HCID 59743548, compound

Participants

Reaction Conditions

Reaction Steps

4-Methylsulfonyl-1-(2-butylsulfonyl-pyrimidin-4-yl)-1H-indole (250 mg, 0.636 mmol), (4-amino-cyclohexyl)-pyrrolidin-1-yl-methanone hydrochloride (444 mg, 1.91 mmol), ethyl-diisopropylamine (333 μL, 1.91 mmol), and dry EtOH (5 mL) were placed in a vial, sealed, and heated in a microwave reactor at 170° C. for 1 h. The product was concentrated to dryness and purified by column chromatography (5% MeOH in DCM), clear fractions collected and evaporated to dryness, and dried overnight under vacuum. The product was recrystallized from CH3CN and dried under vacuum to provide {4-[4-(4-methanesulfonyl-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexyl}-pyrrolidin-1-yl-methanone (Compound 200, 89 mg).

Provenance & Evidence