5-Chloro-1-indanone → HCID 57982434, compound

HRID 1947083Notes

Reaction equation

HRID 1947083 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=O)[CH2:6][CH2:5]2.C(OC([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 1425995-Chloro-1-indanoneHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 57982434HCID 57982434, compound

Procedure

The title compound was prepared in two steps by a standard reductive amination starting with 5-chloro-1-indanone and piperazine carboxylic acid tert-butyl ester followed by removal of the t-Boc group with HCl in 30% overall yield.

Workup

  1. customfollowed by removal of the t-Boc group with HCl in 30% overall yield

Sources & evidence

ORD record
ord-89c38508c9df43c1aac11a0aa2100056
Source dataset
uspto-grants-2013_03
Patent number
US08399455B2

Reaction notes

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